Technology Process of 2-(2-(4'-(2-fluoroacetamido)biphenyl-4-ylsulfonyl)phenyl)acetic acid
There total 7 articles about 2-(2-(4'-(2-fluoroacetamido)biphenyl-4-ylsulfonyl)phenyl)acetic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 0 ℃;
for 5h;
DOI:10.1021/jm4001743
- Guidance literature:
-
Multi-step reaction with 2 steps
1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
2: trifluoroacetic acid / dichloromethane / 5 h / 0 °C
With
N-ethyl-N,N-diisopropylamine; trifluoroacetic acid;
In
dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm4001743
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium hydroxide; copper / water / 0.2 h / 140 °C / 5171.62 Torr / Microwave irradiation
2: toluene / 3 h / 95 °C
3: oxone||potassium monopersulfate triple salt / water; methanol; tetrahydrofuran / 20 h
4: potassium phosphate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 5 h / 85 °C / Inert atmosphere
5: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 20 °C
6: trifluoroacetic acid / dichloromethane / 5 h / 0 °C
With
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); oxone||potassium monopersulfate triple salt; copper; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; potassium hydroxide;
In
tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
4: |Suzuki Coupling;
DOI:10.1021/jm4001743
