(2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

Base Information

Chemical Name:(2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline
CAS No.:304850-92-8
Molecular Formula:C₃₃H₃₁NO₄
Molecular Weight:505.613
Hs Code.:

Synonyms:(2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

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Chemical Property of (2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

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Technology Process of (2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

There total 1 articles about (2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 459-64-3
4-methoxybenzenediazonium tetrafluoroborate

: 223595-45-7
(5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-pyrroline

: 304850-92-8
(2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

Guidance literature:: With sodium acetate; Pd₂(dba)4; In acetonitrile; for 0.333333h;
DOI:10.1016/S0040-4039(03)00017-0

Reference yield: 85.0%

: 304850-92-8
(2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

: 223595-49-1
(2S,5S)-N-(methoxycarbonyl)-5-(hydroxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

: (2R,5S)-N-(methoxycarbonyl)-5-(hydroxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

Guidance literature:: With zinc dibromide; In methanol; dichloromethane; at 20 ℃; for 0.25h;
DOI:10.1021/ol005762d

Reference yield:

: 304850-92-8
(2RS,5S)-N-(methoxycarbonyl)-5-(trityloxymethyl)-2-(p-methoxyphenyl)-3-pyrroline

: (2R,3S,4R,5R)-N-(methoxycarbonyl)-3,4-epoxy-5-(methyl)-2-(p-methoxyphenyl)-pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / ZnBr₂ / CH₂Cl₂; methanol / 0.25 h / 20 °C

2: TEA / CH₂Cl₂ / 0 °C

3: NaBH₄ / dimethylformamide / 1 h / 105 °C

4: m-CPBA / toluene / 24 h / 20 °C

With sodium tetrahydroborate; TEA; 3-chloro-benzenecarboperoxoic acid; zinc dibromide; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; 1: Substitution / 2: Substitution / 3: Reduction / 4: Epoxidation;
DOI:10.1021/ol005762d