1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one

Base Information

• Chemical Name: 1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one
• CAS No.: 142465-22-3
• Molecular Formula: C₁₇H₁₄N₄OS₂
• Molecular Weight: 354.456

Synonyms:1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one

Chemical Property of 1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one

Chemical Property:

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Technology Process of 1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one

There total 9 articles about 1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

carbon disulfide (75-15-0,12122-00-8) + 2-hydrazinyl-3-phenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one (142465-12-1) → 1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one (142465-22-3)

Guidance literature:

With potassium hydroxide; In ethanol; for 16h; Heating;

DOI:10.1002/jhet.5570450226

Reference yield:

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate (4506-71-2) → 1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one (142465-22-3)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene; toluene / 3 h / 120 °C

2: 10percent aq. KOH / 3 h / Heating

3: 47 percent / POCl₃, PCl₃ / 18 h / 110 - 120 °C

4: 85 percent / hydrazine hydrate / aq. ethanol / 0.03 h / Heating

5: 64 percent / pyridine / 18 h / Heating

With pyridine; potassium hydroxide; hydrazine hydrate; trichlorophosphate; phosphorus trichloride; In ethanol; toluene; benzene;

Reference yield:

2-(3-phenyl-ureido)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester (27285-12-7) → 1-mercapto-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one (142465-22-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 10percent aq. KOH / 3 h / Heating

2: 47 percent / POCl₃, PCl₃ / 18 h / 110 - 120 °C

3: 85 percent / hydrazine hydrate / aq. ethanol / 0.03 h / Heating

4: 64 percent / pyridine / 18 h / Heating

With pyridine; potassium hydroxide; hydrazine hydrate; trichlorophosphate; phosphorus trichloride; In ethanol;

upstream raw materials:

carbon disulfide

2-hydrazinyl-3-phenyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one

ethyl 2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate

2-(3-phenyl-ureido)-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester

Downstream raw materials:

1-hydroxy-4-phenyl-6,7,8,9-tetrahydro<1,2,4>triazolo<4,3-a>benzothieno<3,2-e>pyrimidin-5(4H)-one

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