(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Base Information

Chemical Name:(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS No.:1618678-50-4
Molecular Formula:C₅₄H₇₆N₆O₉S
Molecular Weight:985.298
Hs Code.:

(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Synonyms:(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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Chemical Property of (2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

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Technology Process of (2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

There total 15 articles about (2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1618678-78-6
2-(2-(2-( 4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetic acid

: 1448189-80-7,2115897-23-7
(2S,4R)-1-[(2S)-2-amino-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide hydrochloride

: 1618678-50-4
(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 1594941-01-1
(7S,8R,9S,13S,14S,17S)-7-(4-(benzyloxy)butyl)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-6-one

: 1618678-50-4
(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: triethylsilane; trifluoroacetic acid / 18 h / 20 °C / Inert atmosphere

1.2: 1 h / 20 °C

2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 0 - 70 °C

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C

4.1: pyridine / 18 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 80 °C / Sealed tube

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

6.2: 0 - 80 °C

7.1: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

With hydrogenchloride; triethylsilane; palladium 10% on activated carbon; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; pyridine; ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1594941-04-4
(7R,8R,9S,13S,14S,17S)-7-(4-(benzyloxy)butyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol

: 1618678-50-4
(2S,4R)-1-((S)-2-(2-(2-(2-(4-(4-((7R,8R,9S,13S,14S,17S)-3,17-dihydroxy-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-7-yl)butyl)-2-oxopiperazin-1-yl)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 0 - 70 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol / 1.5 h / 20 °C

3.1: pyridine / 18 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 72 h / 80 °C / Sealed tube

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

5.2: 0 - 80 °C

6.1: hydrogenchloride / tetrahydrofuran; water / 16 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 20 °C

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; pyridine; ethanol; water; N,N-dimethyl-formamide; mineral oil;