N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

Base Information

Chemical Name:N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester
CAS No.:288582-38-7
Molecular Formula:C₄₇H₅₅N₃O₁₁
Molecular Weight:837.967
Hs Code.:

N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

Synonyms:N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

Suppliers and Price of N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

There total 3 articles about N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

: 146432-42-0
2-[bis(benzyloxycarbonylmethyl)amino]ethyl bromide

: 288582-37-6
N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

: 288582-38-7
N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

Guidance literature:: With phosphate buffer; In water; acetonitrile; pH=8; Heating;
DOI:10.1021/jo000071g

Reference yield:

: 133099-79-3
D-serine benzyl ester

: 288582-38-7
N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylethylamine; (CF₃SO₂)2O / CH₂Cl₂ / 0.75 h / -20 °C

1.2: 68 percent / diisopropylethylamine / CH₂Cl₂ / -20 - -8 °C

2.1: 27 percent / phosphate buffer / acetonitrile; H₂O / pH 8 / Heating

With phosphate buffer; trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile; 1.1: sulfonation / 1.2: Substitution / 2.1: Alkylation;
DOI:10.1021/jo000071g

Reference yield:

: 89813-47-8
N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester

: 288582-38-7
N-[2-bis[(benzyloxycarbonyl)methyl]aminoethyl]-N-[(2S,4S)-4-[2-(benzyloxycarbonyl)-1-(tert-butyloxycarbonyl)pyrrolidinyl]]-D-serine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: diisopropylethylamine; (CF₃SO₂)2O / CH₂Cl₂ / 0.75 h / -20 °C

1.2: 68 percent / diisopropylethylamine / CH₂Cl₂ / -20 - -8 °C

2.1: 27 percent / phosphate buffer / acetonitrile; H₂O / pH 8 / Heating

With phosphate buffer; trifluoromethylsulfonic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; acetonitrile; 1.1: sulfonation / 1.2: Substitution / 2.1: Alkylation;
DOI:10.1021/jo000071g