4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide

Base Information

Chemical Name:4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide
CAS No.:1256589-18-0
Molecular Formula:C₂₈H₃₂N₆O₃
Molecular Weight:500.6
Hs Code.:

Synonyms:4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide

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Chemical Property of 4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide

Chemical Property:

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Technology Process of 4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide

There total 9 articles about 4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1256592-17-2
1-[(4-BOC-amino-ethyl)-piperidine-1-carbonyl]-3,5-bis-(4-carbamimidoyl-phenoxy)-benzene

: 1256589-18-0
4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide

Guidance literature:: With hydrogenchloride; ethanol; at 5 - 10 ℃; for 2h;
DOI:10.1016/j.bmc.2014.04.013

Reference yield:

: 1194-02-1,143234-87-1
4-fluorobenzonitrile

: 1256589-18-0
4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 80 °C

2.1: lithium hydroxide; water / tetrahydrofuran / 2 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 5 °C

3.2: 20 °C

4.1: hydroxylamine / ethanol; water / 6 h / 75 °C

5.1: acetic acid / 2 h / 20 °C

6.1: acetic acid; zinc / 20 °C

7.1: hydrogenchloride; ethanol / 2 h / 5 - 10 °C

With hydrogenchloride; ethanol; water; hydroxylamine; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.04.013

Reference yield:

: 1256592-07-0
ethyl 3,5-bis(4-cyanophenoxy)benzoate

: 1256589-18-0
4,4'-((5-(4-(2-aminoethyl)piperidine-1-carbonyl)-1,3-phenylene)bis(oxy))dibenzimidamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium hydroxide; water / tetrahydrofuran / 2 h

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.17 h / 5 °C

2.2: 20 °C

3.1: hydroxylamine / ethanol; water / 6 h / 75 °C

4.1: acetic acid / 2 h / 20 °C

5.1: acetic acid; zinc / 20 °C

6.1: hydrogenchloride; ethanol / 2 h / 5 - 10 °C

With hydrogenchloride; ethanol; water; hydroxylamine; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; zinc; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2014.04.013