2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate

Base Information

Chemical Name:2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate
CAS No.:1174428-96-6
Molecular Formula:C₂₄H₂₆N₂O₆S
Molecular Weight:470.546
Hs Code.:

Synonyms:2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate

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Chemical Property of 2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate

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Technology Process of 2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate

There total 5 articles about 2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1174429-23-2
3-bromo-5-morpholino-7H-thieno[3,2-b]pyran-7-one

: 7372-79-4
2-morpholinoethyl 4-iodobenzoate

: 1174428-96-6
2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate

Guidance literature:: With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; bis(pinacol)diborane; In 1,2-dimethoxyethane; at 140 ℃; for 0.25h; Microwave irradiation;
DOI:10.1021/jm301522m

Reference yield:

: 1696-20-4
4-acetylmorpholine

: 1174428-96-6
2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoromethylsulfonic anhydride / dichloromethane / 20 °C

3.1: bis(pinacol)diborane; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 140 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trifluoromethylsulfonic anhydride; caesium carbonate; bis(pinacol)diborane; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane;
DOI:10.1021/jm301522m

Reference yield:

: 95201-93-7
methyl 3-hydroxy-4-bromo-2-thiophenecarboxylate

: 1174428-96-6
2-morpholinoethyl 4-(5-morpholino-7-oxo-7H-thieno[3,2-b]pyran-3-yl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h / 0 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: trifluoromethylsulfonic anhydride / dichloromethane / 20 °C

3.1: bis(pinacol)diborane; caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane / 0.25 h / 140 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; trifluoromethylsulfonic anhydride; caesium carbonate; bis(pinacol)diborane; lithium diisopropyl amide; In tetrahydrofuran; 1,2-dimethoxyethane; hexane; dichloromethane;
DOI:10.1021/jm301522m