tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate

Base Information

Chemical Name:tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate
CAS No.:1246362-00-4
Molecular Formula:C₃₉H₅₅BFN₃O₆
Molecular Weight:691.692
Hs Code.:

tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate

Synonyms:tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate

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Chemical Property of tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate

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Technology Process of tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate

There total 1 articles about tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1246076-74-3
7-fluoro-1-(3-methoxypropyl)-3-methyl-2-(piperidin-3-yl)-1H-indole

: 1246361-96-5
(R)-3-(tert-butoxycarbonylamino)-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butanoic acid

: 1246362-00-4
tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate

Guidance literature:: With 4-methyl-morpholine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield: 69.0%

: 709652-82-4
2-amino-5-bromonicotinonitrile

: 1246362-00-4
tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate

: 1246362-01-5
tert-butyl (2R)-1-(4-(6-amino-5-cyanopyridin-3-yl)phenyl)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxobutan-2-ylcarbamate

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 110 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;

Reference yield:

: 911112-04-4
2-[(5-bromopyridin-2-yl)amino]ethanol

: 1246362-00-4
tert-butyl (2R)-4-(3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-4-oxo-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)butan-2-ylcarbamate

: 1246362-03-7
tert-butyl (R)-4-((R)-3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-1-(4-(6-(2-hydroxyethylamino)pyridin-3-yl)phenyl)-4-oxobutan-2-ylcarbamate

: 1246362-02-6
tert-butyl (R)-4-((S)-3-(7-fluoro-1-(3-methoxypropyl)-3-methyl-1H-indol-2-yl)piperidin-1-yl)-1-(4-(6-(2-hydroxyethylamino)pyridin-3-yl)phenyl)-4-oxobutan-2-ylcarbamate

Guidance literature:: With sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water; at 110 ℃; for 0.166667h; Inert atmosphere; Microwave irradiation;