1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline

Base Information

Chemical Name:1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline
CAS No.:1417409-16-5
Molecular Formula:C₂₁H₁₉ClFN₅O
Molecular Weight:411.866
Hs Code.:

Synonyms:1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline

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Chemical Property of 1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline

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Technology Process of 1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline

There total 6 articles about 1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 110-91-8,99108-56-2
morpholine

: 1417411-66-5
C₁₇H₁₀ClFN₄O

: 1417409-16-5
1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline

Guidance literature:: morpholine; C₁₇H₁₀ClFN₄O; In 1,2-dichloro-ethane; at 120 ℃; for 0.25h; Microwave irradiation;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 80 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 1417411-02-9
8-bromo-1-(2-chloro-6-fluorophenyl)-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

: 1417409-16-5
1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / toluene / 1.5 h / 120 °C

2.1: osmium(VIII) oxide; sodium periodate / water; 1,4-dioxane; tert-butyl alcohol / 2.5 h / 20 °C

3.1: 1,2-dichloro-ethane / 0.25 h / 120 °C / Microwave irradiation

3.2: 0.33 h / 80 °C / Microwave irradiation

With sodium periodate; osmium(VIII) oxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride; In 1,4-dioxane; water; 1,2-dichloro-ethane; toluene; tert-butyl alcohol;

Reference yield:

: 1417411-03-0
1-(2-chloro-6-fluorophenyl)-8-ethenyl-4-methyl[1,2,4]triazolo[4,3-a]quinoxaline

: 1417409-16-5
1-(2-chloro-6-fluorophenyl)-4-methyl-8-(morpholin-4-ylmethyl)[1,2,4]triazolo[4,3-a]quinoxaline

Guidance literature:: Multi-step reaction with 2 steps

1.1: osmium(VIII) oxide; sodium periodate / water; 1,4-dioxane; tert-butyl alcohol / 2.5 h / 20 °C

2.1: 1,2-dichloro-ethane / 0.25 h / 120 °C / Microwave irradiation

2.2: 0.33 h / 80 °C / Microwave irradiation

With sodium periodate; osmium(VIII) oxide; In 1,4-dioxane; water; 1,2-dichloro-ethane; tert-butyl alcohol;