diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate

Base Information

Chemical Name:diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate
CAS No.:940692-54-6
Molecular Formula:C₂₂H₂₇NO₇
Molecular Weight:417.459
Hs Code.:

Synonyms:diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate

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Chemical Property of diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate

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Technology Process of diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate

There total 4 articles about diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 36422-60-3
diethyl 2,6-dimethyl-4-(3,4,5-trimethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylate

: 940692-54-6
diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate

Guidance literature:: With Trametes versicolor laccase (E_.C_. 1.10.3.2); oxygen; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In aq. phosphate buffer; acetonitrile; at 20 ℃; for 6h; Enzymatic reaction;
DOI:10.1016/j.crci.2019.03.003

Reference yield:

: 141-97-9
ethyl acetoacetate

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 940692-54-6
diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate; phenylboronic acid / ethanol / 5 h / Reflux

2: acetic acid; manganese triacetate / 2 h / 27 °C

With ammonium acetate; manganese triacetate; acetic acid; phenylboronic acid; In ethanol; 1: |Hantzsch Pyridine Synthesis;
DOI:10.1039/c6ra28299g

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 940692-54-6
diethyl 2,6?dimethyl?4?(3,4,5?trimethoxyphenyl)pyridine?3,5?dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide / ethanol / 78 °C

2: sodium chlorite; hydrogenchloride / ethanol; water / 20 °C

With hydrogenchloride; ammonium hydroxide; sodium chlorite; In ethanol; water; 1: |Hantzsch Dihydropyridine Synthesis;
DOI:10.1016/j.tetlet.2016.05.061