1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol

Base Information

• Chemical Name: 1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol
• CAS No.: 502688-88-2
• Molecular Formula: C₃₇H₃₆N₄OS
• Molecular Weight: 584.785
• Mol file: 502688-88-2.mol

Synonyms:1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol

Chemical Property of 1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol

There total 3 articles about 1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-2-(tetrahydropyran-2-ylsulfanyl)-propane → 1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol (502688-88-2)

Guidance literature:

With trifluoroacetic acid; at 80 ℃; for 1.5h;

DOI:10.1039/b207770a

Reference yield:

2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-2-(tetrahydro-pyran-2-ylsulfanyl)-propan-1-ol → 1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol (502688-88-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 1.25 h / 20 °C

1.2: dimethylformamide / 24 h

2.1: TFA / 1.5 h / 80 °C

With sodium hydride; trifluoroacetic acid; In N,N-dimethyl-formamide;

DOI:10.1039/b207770a

Reference yield:

4,5-diphenyl-1-methyl-1H-imidazole (50609-88-6) → 1-methoxy-2-methyl-1,1-bis-(1-methyl-4,5-diphenyl-1H-imidazol-2-yl)-propane-2-thiol (502688-88-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: n-BuLi / tetrahydrofuran; hexane; diethyl ether / -78 - 20 °C

1.2: tetrahydrofuran; hexane; diethyl ether / 40 h / 20 °C

1.3: tetrahydrofuran; hexane; diethyl ether / 2 h / Heating

2.1: NaH / dimethylformamide / 1.25 h / 20 °C

2.2: dimethylformamide / 24 h

3.1: TFA / 1.5 h / 80 °C

With n-butyllithium; sodium hydride; trifluoroacetic acid; In tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;

DOI:10.1039/b207770a

upstream raw materials:

4,5-diphenyl-1-methyl-1H-imidazole

Downstream raw materials:

CH₃Zn[(C₆H₅)2C₃N₂(CH₃)]2C(OCH₃)[C(CH₃)2S]

Zn2(μ-SC(CH3)2C(OCH3)(CH3C3N2(C6H5)2)2)2