1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine

Base Information

• Chemical Name: 1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine
• CAS No.: 125345-81-5
• Molecular Formula: C₂₀H₂₃ClF₂N₂O
• Molecular Weight: 380.865

Synonyms:1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine

Chemical Property of 1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine

Chemical Property:

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Technology Process of 1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine

There total 1 articles about 1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.9%

1-(4-fluorophenyl)methyl-piperazine (27469-60-9) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine (125345-81-5)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; for 18h; Ambient temperature;

DOI:10.1021/jm00102a001

Reference yield: 93.1%

2-Mercaptobenzothiazole (149-30-4,118090-09-8) + 1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine (125345-81-5) → 2-[1-[1-[Bis(4-fluorophenyl)methyl]-piperazin-4-yl]-2-hydroxy-3-propanylthio]-benzothiazole Monomalonate Dihydrate

Guidance literature:

With malonic acid; triethylamine; In methanol; ethanol;

Reference yield: 61.9%

7-Phenyl-7H-purine-6-thiol + 1-(1-chloro-2-hydroxy-3-propanyl)-4-[bis(4-fluorophenyl)-methyl]-piperazine (125345-81-5) → 1-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl}-3-(7-phenyl-7H-purin-6-ylsulfanyl)-propan-2-ol

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; for 22h; Ambient temperature;

DOI:10.1021/jm00102a001

upstream raw materials:

1-(4-fluorophenyl)methyl-piperazine

epichlorohydrin

Downstream raw materials:

4--α-<(9H-purin-6-ylthio)methyl>-1-piperazineethanol

4--α-<(9H-purin-6-ylthio)methyl>-1-piperazineethanol acetate

2-[1-[1-[Bis (4-fluorophenyl)-methyl] piperazin-4-yl]-2-hydroxy-3-propanylthio]pyrimidine

4-[1-[1-[Bis(4-fluorophenyl)methyl]piperazin-4-yl]-2-acetoxy-3-propanylthio]pyridine

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