dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

Base Information

Chemical Name:dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate
CAS No.:1415922-52-9
Molecular Formula:C₁₃H₁₇F₃NO₅P
Molecular Weight:355.251
Hs Code.:

Synonyms:dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

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Chemical Property of dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

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Technology Process of dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

There total 4 articles about dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.6%

: 1415922-84-7
dimethyl (1-acetamido-2-oxo-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

: 1415922-52-9
dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

Guidance literature:: With dichloro(benzene)ruthenium(II) dimer; cerium(III) chloride heptahydrate; hydrogen; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine); In methanol; at 50 ℃; for 24h; under 7500.75 Torr; enantioselective reaction; Schlenk technique; Autoclave;
DOI:10.1021/ol303105d

Reference yield:

: 2967-66-0
methyl 4-(trifluoromethyl)benzoate

: 1415922-52-9
dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium diisopropyl amide / tetrahydrofuran / -5 - 0 °C / Inert atmosphere

2: sodium acetate / methanol; water / 2.17 h / 0 - 50 °C / Inert atmosphere

3: zinc; acetic acid / 5 h / 20 °C / Inert atmosphere

4: dichloro(benzene)ruthenium(II) dimer; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine); cerium(III) chloride heptahydrate; hydrogen / methanol / 24 h / 50 °C / 7500.75 Torr / Schlenk technique; Autoclave

With dichloro(benzene)ruthenium(II) dimer; cerium(III) chloride heptahydrate; hydrogen; sodium acetate; acetic acid; zinc; lithium diisopropyl amide; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine); In tetrahydrofuran; methanol; water;
DOI:10.1021/ol303105d

Reference yield:

: 51638-15-4
dimethyl (2-oxo-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

: 1415922-52-9
dimethyl (1-acetamido-2-hydroxy-2-(4-(trifluoromethyl)phenyl)ethyl)phosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate / methanol; water / 2.17 h / 0 - 50 °C / Inert atmosphere

2: zinc; acetic acid / 5 h / 20 °C / Inert atmosphere

3: dichloro(benzene)ruthenium(II) dimer; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine); cerium(III) chloride heptahydrate; hydrogen / methanol / 24 h / 50 °C / 7500.75 Torr / Schlenk technique; Autoclave

With dichloro(benzene)ruthenium(II) dimer; cerium(III) chloride heptahydrate; hydrogen; sodium acetate; acetic acid; zinc; (2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine); In methanol; water;
DOI:10.1021/ol303105d