1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol

Base Information

Chemical Name:1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol
CAS No.:203639-03-6
Molecular Formula:C₁₉H₃₀N₂O₇
Molecular Weight:398.456
Hs Code.:

Synonyms:1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol

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Chemical Property of 1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol

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Technology Process of 1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol

There total 3 articles about 1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 107-30-2
chloromethyl methyl ether

: 203639-01-4
1-(N-benzyloxycarbonyl-L-threonylamino)-2-propanol

: 203639-03-6
1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; 0 deg C, 30 min, rt, 24 h;
DOI:10.1246/cl.1998.139

Reference yield:

: 160821-18-1
(4S,5R)-3-((benzyloxy)carbonyl)-2,2,5-trimethyloxazolidine-4-carboxylic acid

: 203639-03-6
1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol

Guidance literature:: Multi-step reaction with 3 steps

1: BOP; DIPEA / acetonitrile / 0 - 20 °C

2: 589 mg / aq. HCl; aq. AcOH / 50 °C

3: 70 percent / DIPEA / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile; 1: Condensation / 2: Hydrolysis / 3: Etherification;
DOI:10.1246/bcsj.72.1561

Reference yield:

: 203638-99-7
(4S,5R)-4-((S)-2-Hydroxy-propylcarbamoyl)-2,2,5-trimethyl-oxazolidine-3-carboxylic acid benzyl ester

: 203639-03-6
1-(N-benzyloxycarbonyl-O-methoxymethyl-L-threonylamino)-2-(O-methoxymethyl)propanol

Guidance literature:: Multi-step reaction with 2 steps

1: 589 mg / aq. HCl; aq. AcOH / 50 °C

2: 70 percent / DIPEA / CH₂Cl₂ / 0 - 20 °C

With hydrogenchloride; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1: Hydrolysis / 2: Etherification;
DOI:10.1246/bcsj.72.1561