1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine

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Chemical Name:1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine
CAS No.:758727-15-0
Molecular Formula:C₂₅H₃₂N₈O₄
Molecular Weight:508.58
Hs Code.:

Synonyms:1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine

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Chemical Property of 1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine

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Technology Process of 1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine

There total 3 articles about 1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 711022-21-8
[5-(4-{2-[2-(4-hydroxy-piperidin-1-yl)-ethylcarbamoyl]-1-methyl-1H-imidazol-4-ylcarbamoyl}-phenylcarbamoyl)-1-methyl-1H-pyrrol-3-yl]-carbamic acid tert-butyl ester

: 758727-15-0
1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃; for 0.5h;
DOI:10.1021/jm049712g

Reference yield:

: 502171-71-3
4-[(4-tert-butoxycarbonylamino-1-methyl-1H-pyrrole-2-carbonyl)-amino]-benzoic acid

: 758727-15-0
1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride; N,N-diisopropylethylamine; 4-(dimethylamino)pyridine / 1-methyl-pyrrolidin-2-one / 0.5 h / 25 °C

1.2: 54 percent / 1-methyl-pyrrolidin-2-one / 0.5 h / 60 °C

2.1: HCl (gas) / methanol / 0.5 h / 20 °C

With hydrogenchloride; dmap; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1021/jm049712g

Reference yield:

: 4-amino-1-methyl-1H-imidazole-2-carboxylic acid [2-(4-hydroxy-piperidin-1-yl)-ethyl]-amide

: 758727-15-0
1-(2-hydroxyethyl)-4-{2-[1-methyl-4-(4-(4-amino-1-methyl-2-pyrrolecarboxamido)-1-benzamido)-2-imidazolecarboxamido]ethyl}piperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis(2-oxo-3-oxazolidinyl)phosphinic acid chloride; N,N-diisopropylethylamine; 4-(dimethylamino)pyridine / 1-methyl-pyrrolidin-2-one / 0.5 h / 25 °C

1.2: 54 percent / 1-methyl-pyrrolidin-2-one / 0.5 h / 60 °C

2.1: HCl (gas) / methanol / 0.5 h / 20 °C

With hydrogenchloride; dmap; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; methanol;
DOI:10.1021/jm049712g