(S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester

Base Information

Chemical Name:(S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester
CAS No.:1026099-48-8
Molecular Formula:C₁₇H₂₇NO₇S₂
Molecular Weight:421.536
Hs Code.:

Synonyms:(S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester

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Chemical Property of (S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester

Chemical Property:

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Technology Process of (S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester

There total 1 articles about (S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34297-27-3
D-penicillamine methyl ester hydrochloride

: 1026099-48-8
(S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethylformamide / 20 °C

2: Et₃N / dioxane; H₂O / 18 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In 1,4-dioxane; water; N,N-dimethyl-formamide; 1: Alkylation / 2: sulfonylation;
DOI:10.1021/jm990330y

Reference yield:

: 1026099-48-8
(S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester

: 1027962-13-5
(S)-7-(4-Methoxy-benzenesulfonyl)-5,5-dimethyl-[1,4,7]oxathiazonane-6-carboxylic acid methyl ester

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jm990330y

Reference yield:

: 1026099-48-8
(S)-3-[2-(2-Hydroxy-ethoxy)-ethylsulfanyl]-2-(4-methoxy-benzenesulfonylamino)-3-methyl-butyric acid methyl ester

: 253194-96-6
4-[(4-methoxyphenyl)sulfonyl]-2,2-dimethyl-octahydro-7-oxa-1,4-thiazonine-3(S)-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: Ph₃P; diethyl azodicarboxylate / tetrahydrofuran / 2 h / 20 °C

2: LiI; pyridine / 3 h / Heating

With pyridine; triphenylphosphine; lithium iodide; diethylazodicarboxylate; In tetrahydrofuran; 1: Cyclization / 2: demethylation;
DOI:10.1021/jm990330y