(S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide

Base Information

• Chemical Name: (S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide
• CAS No.: 1000072-74-1
• Molecular Formula: C₁₄H₂₁N₃O
• Molecular Weight: 247.34
• Mol file: 1000072-74-1.mol

Synonyms:(S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide

Chemical Property of (S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide

There total 2 articles about (S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

C3H5NO + (S)-2-amino-3-methyl-N-phenylbutanamide (129473-55-8) → (S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide (1000072-74-1)

Guidance literature:

C₃H₅NO; (S)-2-amino-3-methyl-N-phenylbutyramide; With zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; at 20 ℃; for 0.0166667h;

With sodium cyanoborohydride; In tetrahydrofuran; methanol; dichloromethane; at 20 ℃;

Reference yield: 51.0%

2-aziridin-2-yl-3-oxa-1-aza-bicyclo[3.1.0]hexan-4-ol + (S)-2-amino-3-methyl-N-phenylbutanamide (129473-55-8) → (S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide (1000072-74-1)

Guidance literature:

With sodium cyanoborohydride; zinc(II) chloride; In tetrahydrofuran; methanol; dichloromethane; at 20 ℃;

DOI:10.1021/ja076155p

Reference yield: 82.0%

thiobenzoic acid (98-91-9) + (S)-2-((R)-aziridin-2-ylmethylamino)-3-methyl-N-phenylbutanamide (1000072-74-1) → S-(S)-2-benzamido-3-((S)-3-methyl-1-oxo-1-(phenylamino)butan-2-ylamino)propyl benzothioate (1000072-75-2)

Guidance literature:

In methanol; dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ja076155p

upstream raw materials:

(S)-2-amino-3-methyl-N-phenylbutanamide

Downstream raw materials:

S-(S)-2-benzamido-3-((S)-3-methyl-1-oxo-1-(phenylamino)butan-2-ylamino)propyl benzothioate