4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

Base Information

Chemical Name:4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide
CAS No.:1352835-98-3
Molecular Formula:C₃₁H₂₉FN₆O₃
Molecular Weight:552.608
Hs Code.:

Synonyms:4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

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Chemical Property of 4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

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Technology Process of 4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

There total 9 articles about 4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.09%

: 1352836-12-4
4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxylic acid

: 1352835-98-3
4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1.5h;

Reference yield:

: 5318-27-4
6-amino-1H-indole

: 1352835-98-3
4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium carbonate / tert-butyl alcohol / 84 h / 100 °C / Sealed tube

2.1: ytterbium(III) triflate / acetonitrile / 20 h / 50 °C

3.1: hydrogen / Raney Ni / methanol / 3 h / 2844.39 Torr

4.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

4.2: pH 10

4.3: 4.5 h / 140 °C

5.1: sodium hydroxide; water / methanol / 0.75 h / Reflux

5.2: pH 5

6.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1.5 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; sodium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; ytterbium(III) triflate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;

Reference yield:

: 245117-18-4
4-(1H-indol-6-yl)morpholine

: 1352835-98-3
4-(3-(4-(dimethylamino)benzamido)-2-fluorophenyl)-7-morpholino-9H-pyrido[3,4-b]indole-1-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: ytterbium(III) triflate / acetonitrile / 20 h / 50 °C

2.1: hydrogen / Raney Ni / methanol / 3 h / 2844.39 Torr

3.1: hydrogenchloride / toluene; 1,4-dioxane / 16 h / 20 °C

3.2: pH 10

3.3: 4.5 h / 140 °C

4.1: sodium hydroxide; water / methanol / 0.75 h / Reflux

4.2: pH 5

5.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4-methyl-morpholine; ammonium chloride / N,N-dimethyl-formamide / 1.5 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; ammonium chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; ytterbium(III) triflate; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; acetonitrile;