5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran

Base Information

Chemical Name:5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran
CAS No.:139201-40-4
Molecular Formula:C₂₉H₃₄O₄S
Molecular Weight:478.653
Hs Code.:

Synonyms:5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran

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Chemical Property of 5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran

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Technology Process of 5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran

There total 12 articles about 5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 138854-69-0
5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylthio)phenyl>ethyl>-6-propylbenzofuran

: 139201-40-4
5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 1.) 5 deg C, 30 min, 2.) RT, 30 min;
DOI:10.1021/jm00085a019

Reference yield:

: 104-95-0
(4-bromophenyl)thioanisole

: 139201-40-4
5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Mg / 1.) THF, reflux, 2 h, 2.) THF, RT, 1 h

2: 25 percent / ZnI, sodium cyanoborohydride / 1,2-dichloro-ethane / 18 h / Heating

3: 89 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 1.5 h / 2068.6 Torr

4: 98 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.) 5 deg C, 30 min, 2.) RT, 30 min

With hydrogen; sodium cyanoborohydride; magnesium; 3-chloro-benzenecarboperoxoic acid; zinc(II) iodide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane;
DOI:10.1021/jm00085a019

Reference yield:

: 100-44-7
benzyl chloride

: 139201-40-4
5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-<4-(methylsulfonyl)phenyl>ethyl>-6-propylbenzofuran

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / K₂CO₃ / butan-2-one / 25 h / Heating

2: 1.) DMSO, oxalyl chloride / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, -78 deg C, 20 min

3: 1.) Mg / 1.) THF, reflux, 2 h, 2.) THF, RT, 1 h

4: 25 percent / ZnI, sodium cyanoborohydride / 1,2-dichloro-ethane / 18 h / Heating

5: 89 percent / H₂ / 10percent Pd/C / ethanol; ethyl acetate / 1.5 h / 2068.6 Torr

6: 98 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 1.) 5 deg C, 30 min, 2.) RT, 30 min

With oxalyl dichloride; hydrogen; sodium cyanoborohydride; potassium carbonate; magnesium; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; zinc(II) iodide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; butanone;
DOI:10.1021/jm00085a019