2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile

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Chemical Name:2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile
CAS No.:1197340-79-6
Molecular Formula:C₂₃H₂₀N₆O₂
Molecular Weight:412.451
Hs Code.:

Synonyms:2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile

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Chemical Property of 2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile

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Technology Process of 2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile

There total 6 articles about 2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₁H₂₈N₆O₃

: 1197340-79-6
2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: With trifluoroacetic acid; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 1197340-84-3
methyl 3-(4-bromophenyl)-4-(4-methoxybenzyloxy)-1H-pyrazole-5-carboxylate

: 1197340-79-6
2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide monohydrate / N,N-dimethyl-formamide / 3 h / 20 °C / Ice bath

2: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 120 °C / Microwave irradiation

3: lithium hydroxide monohydrate / methanol / 0.33 h / 120 °C / Microwave irradiation

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

5: acetic acid / 0.92 h / 150 °C / Microwave irradiation

6: trifluoroacetic acid / 0.5 h / 120 °C / Microwave irradiation

With lithium hydroxide monohydrate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;

Reference yield:

: 1197340-73-0
methyl 3-(4-bromophenyl)-4-(4-methoxybenzyloxy)-1-methyl-1H-pyrazole-5-carboxylate

: 1197340-79-6
2-(4-hydroxy-1-methyl-3-(4-(2-oxopiperidin-1-yl)phenyl)-1H-pyrazol-5-yl)-1H-benzo[d]imidazole-5-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 1 h / 120 °C / Microwave irradiation

2: lithium hydroxide monohydrate / methanol / 0.33 h / 120 °C / Microwave irradiation

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4: acetic acid / 0.92 h / 150 °C / Microwave irradiation

5: trifluoroacetic acid / 0.5 h / 120 °C / Microwave irradiation

With lithium hydroxide monohydrate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;