Technology Process of methyl N-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]carbamate
There total 2 articles about methyl N-[2-(3-hydroxyprop-1-yn-1-yl)phenyl]carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); triethylamine;
In
tetrahydrofuran;
at 40 ℃;
for 2h;
Inert atmosphere;
DOI:10.1021/jo4022293
- Guidance literature:
-
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere; Sealed tube
2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 20 °C / Inert atmosphere; Sealed tube
With
pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine;
In
tetrahydrofuran; dichloromethane;
2: |Sonogashira Cross-Coupling;
DOI:10.1021/acs.joc.1c01379
- Guidance literature:
-
With
2,2,2-trifluoroethanol; di-isopropyl azodicarboxylate; N-isopropylidene-N’-2-nitrobenzenesulfonyl hydrazine; water; triphenylphosphine;
In
tetrahydrofuran;
at 0 - 20 ℃;
for 4h;
Inert atmosphere;
Sealed tube;
DOI:10.1021/acs.joc.1c01379
