3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester

Base Information

• Chemical Name: 3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester
• CAS No.: 350238-20-9
• Molecular Formula: C₂₇H₂₅ClN₂O₆
• Molecular Weight: 508.958

Synonyms:3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester

Chemical Property of 3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester

Chemical Property:

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Technology Process of 3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester

There total 4 articles about 3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

ethyl potassium malonate (6148-64-7) + [(7-chloro-4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-phenyl-methyl]-carbamic acid benzyl ester (350238-19-6) → 3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester (350238-20-9)

Guidance literature:

With triethylamine; magnesium chloride; In acetonitrile;

DOI:10.1016/S0040-4039(01)00402-6

Reference yield:

(Chlorocarbonyl-phenyl-methyl)-carbamic acid benzyl ester (61464-95-7) → 3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester (350238-20-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / tetrahydrofuran

2: 75 percent / Ac₂O

3: 87 percent / MgCl₂; Et₃N / acetonitrile

With acetic anhydride; triethylamine; magnesium chloride; In tetrahydrofuran; acetonitrile;

DOI:10.1016/S0040-4039(01)00402-6

Reference yield:

2-Amino-4-chlorobenzoic acid (89-77-0) → 3-[2-(2-benzyloxycarbonylamino-2-phenyl-acetylamino)-4-chloro-phenyl]-3-oxo-propionic acid ethyl ester (350238-20-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / tetrahydrofuran

2: 75 percent / Ac₂O

3: 87 percent / MgCl₂; Et₃N / acetonitrile

With acetic anhydride; triethylamine; magnesium chloride; In tetrahydrofuran; acetonitrile;

DOI:10.1016/S0040-4039(01)00402-6

upstream raw materials:

ethyl potassium malonate

[(7-chloro-4-oxo-4H-benzo[d][1,3]oxazin-2-yl)-phenyl-methyl]-carbamic acid benzyl ester

(Chlorocarbonyl-phenyl-methyl)-carbamic acid benzyl ester

2-Amino-4-chlorobenzoic acid

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