benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide

Base Information

Chemical Name:benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide
CAS No.:1418023-59-2
Molecular Formula:C₂₇H₁₈ClN₃O₅
Molecular Weight:499.91
Hs Code.:

Synonyms:benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide

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Chemical Property of benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide

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Technology Process of benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide

There total 9 articles about benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 25054-53-9
3,4-(methylenedioxy)benzoyl chloride

: 1418025-72-5
3-aminomethyl-7-chloro-2-oxazol-2-yl-1-phenyl-1H-quinolin-4-one trifluoroacetate

: 1418023-59-2
benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; under 760.051 Torr; Inert atmosphere;

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418023-59-2
benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 760.05 Torr / Inert atmosphere; Reflux

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / 760.05 Torr / Inert atmosphere

4.2: 5 h / 20 °C / 760.05 Torr / Inert atmosphere

5.1: dichloromethane / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hexamethyldisilazane; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418023-59-2
benzo[1,3]dioxole-5-carboxylic acid (7-chloro-2-oxazol-2-yl-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hexamethyldisilazane / N,N-dimethyl-formamide; tetrahydrofuran / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 2 h / 760.05 Torr / Inert atmosphere; Reflux

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / 760.05 Torr / Inert atmosphere

3.2: 5 h / 20 °C / 760.05 Torr / Inert atmosphere

4.1: dichloromethane / 2 h / 20 °C / 760.05 Torr / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; dmap / dichloromethane / 20 °C / 760.05 Torr / Inert atmosphere

With dmap; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium hexamethyldisilazane; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; mineral oil;