N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine

Base Information

• Chemical Name: N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine
• CAS No.: 180397-82-4
• Molecular Formula: C₃₆H₄₄N₂O₈
• Molecular Weight: 632.754
• Mol file: 180397-82-4.mol

Synonyms:N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine

Chemical Property of N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine

There total 5 articles about N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

di-tert-butyl dicarbonate (24424-99-5) + N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine (180397-81-3) → N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine (180397-82-4)

Guidance literature:

With dmap; In chloroform; for 3h; Ambient temperature;

Reference yield:

p-xylylidenediamine (539-48-0) → N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine (180397-82-4)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / Heating

2: NaBH₄ / methanol / Heating

3: DMAP / CH₂Cl₂

With dmap; sodium tetrahydroborate; In methanol; dichloromethane; toluene; 1: Condensation / 2: Reduction / 3: Acylation;

DOI:10.1021/jo991397w

Reference yield:

C26H24N2O4 (180397-80-2) → N,N'-bis(tert-butoxycarbonyl)-N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine (180397-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄ / methanol / Heating

2: DMAP / CH₂Cl₂

With dmap; sodium tetrahydroborate; In methanol; dichloromethane; 1: Reduction / 2: Acylation;

DOI:10.1021/jo991397w

upstream raw materials:

di-tert-butyl dicarbonate

N,N'-bis(4-carbomethoxybenzyl)-p-xylenediamine

p-xylylidenediamine

C₂₆H₂₄N₂O₄

Downstream raw materials:

(4-{[tert-Butoxycarbonyl-(4-hydroxymethyl-benzyl)-amino]-methyl}-benzyl)-(4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester

(4-{[tert-Butoxycarbonyl-(4-chloromethyl-benzyl)-amino]-methyl}-benzyl)-(4-chloromethyl-benzyl)-carbamic acid tert-butyl ester

(4-Azidomethyl-benzyl)-(4-{[(4-azidomethyl-benzyl)-tert-butoxycarbonyl-amino]-methyl}-benzyl)-carbamic acid tert-butyl ester

N,N'-bis(4-azidomethylbenzyl)-p-xylylenediamine