2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol

Base Information

• Chemical Name: 2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol
• CAS No.: 528608-97-1
• Molecular Formula: C₁₄H₂₂O₅
• Molecular Weight: 270.326
• Mol file: 528608-97-1.mol

Synonyms:2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol

Chemical Property of 2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol

There total 3 articles about 2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4-(2-benzyloxy-ethoxymethyl)-1-methyl-2,6,7-trioxa-bicyclo[2.2.2]octane (528608-96-0) → 2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol (528608-97-1)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 6h;

DOI:10.1002/ejic.200390019

Reference yield:

benzyl 2-chloroethyl ether (17229-17-3) → 2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol (528608-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / KOH / dimethylsulfoxide / 2 h / 60 °C

2: 86 percent / aq. HCl / methanol / 6 h / 20 °C

With hydrogenchloride; potassium hydroxide; In methanol; dimethyl sulfoxide;

DOI:10.1002/ejic.200390019

Reference yield:

1-methyl-4-(hydroxymethyl)-2,6,7-trioxabicyclo-[2.2.2]-octane (19309-39-8) → 2-(2-benzyloxy-ethoxymethyl)-2-hydroxymethyl-propane-1,3-diol (528608-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / KOH / dimethylsulfoxide / 2 h / 60 °C

2: 86 percent / aq. HCl / methanol / 6 h / 20 °C

With hydrogenchloride; potassium hydroxide; In methanol; dimethyl sulfoxide;

DOI:10.1002/ejic.200390019

upstream raw materials:

4-(2-benzyloxy-ethoxymethyl)-1-methyl-2,6,7-trioxa-bicyclo[2.2.2]octane

benzyl 2-chloroethyl ether

1-methyl-4-(hydroxymethyl)-2,6,7-trioxabicyclo-[2.2.2]-octane

Downstream raw materials:

2-{3-diphenylphosphanyl-2,2-bis-[(diphenylphosphanyl)-methyl]-propoxy}-ethanol

C₃₄H₄₈O₁₁S₃Si

C₂₈H₃₄O₁₁S₃

C₃₅H₄₀O₁₁S₃