C₅₁H₇₆O₁₀Si

Base Information

• Chemical Name: C₅₁H₇₆O₁₀Si
• CAS No.: 161984-89-0
• Molecular Formula: C₅₁H₇₆O₁₀Si
• Molecular Weight: 877.244
• Mol file: 161984-89-0.mol

Synonyms:C₅₁H₇₆O₁₀Si

Chemical Property of C₅₁H₇₆O₁₀Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₁H₇₆O₁₀Si

There total 43 articles about C₅₁H₇₆O₁₀Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C51H78O10Si → C51H76O10Si (161984-89-0)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 25 ℃; for 2h; Yield given;

DOI:10.1021/ja00108a052 DOI:10.1021/ja00146a010

Reference yield:

(2R,4aR,8aR,9aS,10aS)-10a-Methyl-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-one (858346-23-3) → C51H76O10Si (161984-89-0)

Guidance literature:

Multi-step reaction with 18 steps

1.1: 94 percent / DMPU; KHMDS / tetrahydrofuran; toluene / 0.5 h / -78 °C

2.1: Zn-Cu; DMA / benzene / 1 h / Heating

2.2: 85 percent / PdCl₂(o-Tol₃P)2 / benzene / 13 h / 40 °C

3.1: BH₃*SMe₂ / tetrahydrofuran / 2 h / 20 °C

3.2: aq. NaOH; H₂O₂ / tetrahydrofuran / 1 h / 20 °C

4.1: 76 percent / 2,6-lutidine / CH₂Cl₂ / 2.5 h / 20 °C

5.1: 56 percent / aq. AcOH / tetrahydrofuran / 3 h / 20 °C

6.1: 90 percent / Bu₃P / dimethylformamide / 2 h / 0 - 20 °C

7.1: NCS / CCl₄; CH₂Cl₂ / 0.5 h / 20 °C

8.1: 146 mg / DTBMP; AgOTf; 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / -10 °C

9.1: TBAF / tetrahydrofuran / 3 h / 20 °C

10.1: CSA / CH₂Cl₂ / 1 h / 20 °C

10.2: TMSI; HMDS / CH₂Cl₂ / 1 h / 0 °C

10.3: AgOTf; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 20 °C

11.1: 72 percent / Grubbs catalyst / benzene / 13 h / 60 °C

12.1: CSA / CH₂Cl₂; methanol / 2 h / 20 °C

13.1: 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

14.1: H₂; Et₃N / Pd/C / ethyl acetate / 2 h

15.1: 53.4 mg / CSA / CH₂Cl₂; methanol / 2.5 h / 0 °C

16.1: NMO; TPAP; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / 20 °C

17.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

18.1: 43.0 mg / NMO; TPAP; 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 20 °C

With 2,6-dimethylpyridine; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N-chloro-succinimide; Grubbs catalyst first generation; N-methyl-2-indolinone; 2,6-di-tert-butyl-4-methylpyridine; tetrapropylammonium perruthennate; tributylphosphine; dimethylsulfide borane complex; 4 A molecular sieve; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; silver trifluoromethanesulfonate; potassium hexamethylsilazane; 2,4-dichlorophenoxyacetic acid dimethylamine; copper; acetic acid; triethylamine; zinc; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; benzene;

DOI:10.1021/ja051171c

Reference yield:

(R)-2-Methyl-3-((2R,4aR,8aR,9aS,10aS)-10a-methyl-2-phenyl-4a,5,8a,9,9a,10a-hexahydro-4H-1,3,8,10-tetraoxa-anthracen-7-yl)-propionic acid methyl ester (858346-25-5) → C51H76O10Si (161984-89-0)

Guidance literature:

Multi-step reaction with 16 steps

1.1: BH₃*SMe₂ / tetrahydrofuran / 2 h / 20 °C

1.2: aq. NaOH; H₂O₂ / tetrahydrofuran / 1 h / 20 °C

2.1: 76 percent / 2,6-lutidine / CH₂Cl₂ / 2.5 h / 20 °C

3.1: 56 percent / aq. AcOH / tetrahydrofuran / 3 h / 20 °C

4.1: 90 percent / Bu₃P / dimethylformamide / 2 h / 0 - 20 °C

5.1: NCS / CCl₄; CH₂Cl₂ / 0.5 h / 20 °C

6.1: 146 mg / DTBMP; AgOTf; 4 Angstroem molecular sieves / CH₂Cl₂ / 1 h / -10 °C

7.1: TBAF / tetrahydrofuran / 3 h / 20 °C

8.1: CSA / CH₂Cl₂ / 1 h / 20 °C

8.2: TMSI; HMDS / CH₂Cl₂ / 1 h / 0 °C

8.3: AgOTf; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 20 °C

9.1: 72 percent / Grubbs catalyst / benzene / 13 h / 60 °C

10.1: CSA / CH₂Cl₂; methanol / 2 h / 20 °C

11.1: 2,6-lutidine / CH₂Cl₂ / 1 h / 20 °C

12.1: H₂; Et₃N / Pd/C / ethyl acetate / 2 h

13.1: 53.4 mg / CSA / CH₂Cl₂; methanol / 2.5 h / 0 °C

14.1: NMO; TPAP; 4 Angstroem molecular sieves / CH₂Cl₂ / 1.5 h / 20 °C

15.1: tetrahydrofuran; diethyl ether / 0.5 h / 0 °C

16.1: 43.0 mg / NMO; TPAP; 4 Angstroem molecular sieves / CH₂Cl₂ / 2 h / 20 °C

With 2,6-dimethylpyridine; N-chloro-succinimide; Grubbs catalyst first generation; N-methyl-2-indolinone; 2,6-di-tert-butyl-4-methylpyridine; tetrapropylammonium perruthennate; tributylphosphine; dimethylsulfide borane complex; 4 A molecular sieve; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; silver trifluoromethanesulfonate; acetic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; benzene;

DOI:10.1021/ja051171c

upstream raw materials:

(2R,4aR,8aR,9aS,10aS)-10a-Methyl-2-phenyl-octahydro-1,3,8,10-tetraoxa-anthracen-7-one

(R)-2-Methyl-3-((2R,4aR,8aR,9aS,10aS)-10a-methyl-2-phenyl-4a,5,8a,9,9a,10a-hexahydro-4H-1,3,8,10-tetraoxa-anthracen-7-yl)-propionic acid methyl ester

Trifluoro-methanesulfonic acid (2R,4aR,8aR,9aS,10aS)-10a-methyl-2-phenyl-4a,5,8a,9,9a,10a-hexahydro-4H-1,3,8,10-tetraoxa-anthracen-7-yl ester

(2R,3S,4aR,6S,7R,8aS)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-2,6,8a-trimethyl-2-vinyl-octahydro-pyrano[3,2-b]pyran-3-ol

Downstream raw materials:

C₄₅H₆₂O₁₀

C₄₉H₆₈O₉

C₄₇H₆₄O₉

C₄₀H₅₈O₁₁S