3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide

Base Information

• Chemical Name: 3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide
• CAS No.: 693257-37-3
• Molecular Formula: C₂₀H₁₆N₂O₅
• Molecular Weight: 364.357
• Mol file: 693257-37-3.mol

Synonyms:3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide

Chemical Property of 3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide

There total 4 articles about 3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 4-bromo-2-methoxybenzoate (139102-34-4) → 3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide (693257-37-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 49 percent / tetrakis-(triphenylphosphine)palladium / various solvent(s) / 24 h / Heating

2: 99 percent / potassium hydroxide / methanol / 3 h / Heating

3: 81 mg / thionyl chloride; DMF / 1.17 h / Heating

4: 160 mg / pyridine / 3.5 h / Heating

With pyridine; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; N,N-dimethyl-formamide; In methanol;

DOI:10.1016/j.ejmech.2003.09.010

Reference yield:

methyl 2-methoxy-4-(4-nitrophenyl)benzoate (693257-44-2) → 3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide (693257-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / potassium hydroxide / methanol / 3 h / Heating

2: 81 mg / thionyl chloride; DMF / 1.17 h / Heating

3: 160 mg / pyridine / 3.5 h / Heating

With pyridine; potassium hydroxide; thionyl chloride; N,N-dimethyl-formamide; In methanol;

DOI:10.1016/j.ejmech.2003.09.010

Reference yield:

2-methoxy-4-(4-nitrophenyl)benzoic acid (693257-42-0) → 3-methoxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide (693257-37-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 mg / thionyl chloride; DMF / 1.17 h / Heating

2: 160 mg / pyridine / 3.5 h / Heating

With pyridine; thionyl chloride; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2003.09.010

upstream raw materials:

3-chloro-aniline

3-methoxy-4'-nitro-biphenyl-4-carbonyl chloride

methyl 4-bromo-2-methoxybenzoate

methyl 2-methoxy-4-(4-nitrophenyl)benzoate

Downstream raw materials:

3-hydroxy-4'-nitro-biphenyl-4-carboxylic acid (3-hydroxy-phenyl)-amide