Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester

Base Information

• Chemical Name: Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester
• CAS No.: 69297-04-7
• Molecular Formula: C₁₃H₂₀O₃
• Molecular Weight: 224.3
• Mol file: 69297-04-7.mol

Synonyms:Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester

Chemical Property of Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester

There total 5 articles about Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1(R),4(S),5(R)-4-ethynyl-4-hydroxy-3,3,5-trimethyl-cyclohexyl acetate (70905-65-6) → Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester (69297-04-7)

Guidance literature:

With benzoic acid; tris-(triphenylsiloxy)-vanadium oxide; In xylene; Heating;

DOI:10.1039/p19960001337

Reference yield: 95.0%

Acetic acid (1R,5R)-3,3,5-trimethyl-4-[2-oxo-eth-(Z)-ylidene]-cyclohexyl ester (214335-59-8) → Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester (69297-04-7)

Guidance literature:

With tris-(triphenylsiloxy)-vanadium oxide; benzoic acid; In xylene; for 6.5h; Heating;

Reference yield:

(4R,6R)-2,2,6-Trimethyl-4-trimethylsilanyloxy-cyclohexanone (152125-31-0) → Acetic acid (R)-3,5,5-trimethyl-4-(2-oxo-ethyl)-cyclohex-3-enyl ester (69297-04-7)

Guidance literature:

Multi-step reaction with 4 steps

1: BuLi / tetrahydrofuran; hexane / 1.) 0 deg C, 20 min, 2.) 0 deg C, 1 h

2: KOH, H₂O / methanol / 0.5 h / Ambient temperature

3: pyridine / 16 h / Ambient temperature

4: 96 percent / tris(triphenylsilyl)vanadate, PhCO₂H / xylene / 6 h / Heating

With pyridine; potassium hydroxide; n-butyllithium; water; tris-(triphenylsiloxy)-vanadium oxide; benzoic acid; In tetrahydrofuran; methanol; hexane; xylene;

upstream raw materials:

1(R),4(S),5(R)-4-ethynyl-4-hydroxy-3,3,5-trimethyl-cyclohexyl acetate

Acetic acid (1R,5R)-3,3,5-trimethyl-4-[2-oxo-eth-(Z)-ylidene]-cyclohexyl ester

1(S),4(R),6(R)-1-ethynyl-2,2,6-trimethyl-1,4-cyclohexanediol

(4R,6R)-2,2,6-Trimethyl-4-trimethylsilanyloxy-cyclohexanone

Downstream raw materials:

(1R)-4-(2-acetoxyethyl)-3,5,5-trimethylcyclohex-3-enyl acetate

3-((4R)-4-acetoxy-2,6,6-trimethylcyclohex-1-enyl)propionitrile

Acetic acid (R)-4-(2-methanesulfonyloxy-ethyl)-3,5,5-trimethyl-cyclohex-3-enyl ester

(1R)-4-ethyl-3,5,5-trimethylcyclohex-3-enyl acetate