Technology Process of (3S,5aR,9R,9aS,9bS)-3,9-Dimethyl-5a-[2-(2-nitro-phenylselanyl)-ethyl]-octahydro-furo[2,3-f]isochromene-2,8-dione
There total 13 articles about (3S,5aR,9R,9aS,9bS)-3,9-Dimethyl-5a-[2-(2-nitro-phenylselanyl)-ethyl]-octahydro-furo[2,3-f]isochromene-2,8-dione which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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13902-54-0,13902-55-1,13902-61-9,14794-68-4,14804-46-7,14804-47-8,14987-66-7,17956-11-5,18409-87-5,32638-47-4,84652-34-6,143521-75-9,143521-76-0
tetrahydrosantonin
- Guidance literature:
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Multi-step reaction with 11 steps
1: boron trifluoride etherate
2: tetramethylammonium acetate / various solvent(s) / 8 h / Heating
3: 100 percent / sodium borohydride / methanol; CH2Cl2 / 0.5 h / -15 - -10 °C
4: 78.5 percent / HgO, I2 / benzene / 3 h / Heating
5: KOH / methanol
6: pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature
7: 26 percent / Zn / ZnI2 or ZnCl2 / acetic acid / Heating
8: pyridinium p-toluenesulfonate / methanol / 3 h / Heating
9: 1) O3, CH3OH + CH2Cl2, -78 deg C, 2) NaBH4, -20 deg C
10: 72 percent / 10 percent HCl / methanol / Heating
11: (C4H9)3P
With
hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; (C4H9)3P; tetramethyl ammonium acetate; iodine; pyridinium p-toluenesulfonate; pyridinium chlorochromate; mercury(II) oxide; zinc;
boron trifluoride diethyl etherate; zinc(II) iodide; zinc(II) chloride;
In
methanol; dichloromethane; acetic acid; benzene;
DOI:10.1016/S0040-4039(00)78702-8
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 26 percent / Zn / ZnI2 or ZnCl2 / acetic acid / Heating
2: pyridinium p-toluenesulfonate / methanol / 3 h / Heating
3: 1) O3, CH3OH + CH2Cl2, -78 deg C, 2) NaBH4, -20 deg C
4: 72 percent / 10 percent HCl / methanol / Heating
5: (C4H9)3P
With
hydrogenchloride; (C4H9)3P; pyridinium p-toluenesulfonate; zinc;
zinc(II) iodide; zinc(II) chloride;
In
methanol; acetic acid;
DOI:10.1016/S0040-4039(00)78702-8
- Guidance literature:
-
Multi-step reaction with 7 steps
1: KOH / methanol
2: pyridinium chlorochromate / CH2Cl2 / 3 h / Ambient temperature
3: 26 percent / Zn / ZnI2 or ZnCl2 / acetic acid / Heating
4: pyridinium p-toluenesulfonate / methanol / 3 h / Heating
5: 1) O3, CH3OH + CH2Cl2, -78 deg C, 2) NaBH4, -20 deg C
6: 72 percent / 10 percent HCl / methanol / Heating
7: (C4H9)3P
With
hydrogenchloride; potassium hydroxide; (C4H9)3P; pyridinium p-toluenesulfonate; pyridinium chlorochromate; zinc;
zinc(II) iodide; zinc(II) chloride;
In
methanol; dichloromethane; acetic acid;
DOI:10.1016/S0040-4039(00)78702-8
