(3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone

Base Information

• Chemical Name: (3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone
• CAS No.: 114107-00-5
• Molecular Formula: C₁₆H₁₅FO₂S
• Molecular Weight: 290.358
• Mol file: 114107-00-5.mol

Synonyms:(3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone

Chemical Property of (3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone

There total 1 articles about (3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-methyl p-tolyl sulfoxide (1519-39-7) + methyl (±)-2-fluoro-2-phenylacetate (17841-30-4) → (3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone (114107-00-5) + (3S)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone (114086-90-7)

Guidance literature:

Yield given. Yields of byproduct given;

DOI:10.1039/c39880000218

Reference yield: 94.0%

(3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone (114107-00-5) → (2S,3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanol (114181-10-1)

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃;

DOI:10.1016/S0040-4039(00)96646-2

Reference yield:

(3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanone (114107-00-5) → (1R,2R)-1-fluoro-3-phenyl-2-propanol (114181-12-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1M DIBAH / hexane; tetrahydrofuran / 0.5 h / -78 °C

2: NaI, (CF₃CO)2O / acetone / 0.33 h / -40 °C

3: 80 percent / H₂ / Raney Ni (W-2) / ethanol / 0.25 h / Heating

With hydrogen; diisobutylaluminium hydride; trifluoroacetic anhydride; sodium iodide; Raney Ni (W-2); In tetrahydrofuran; ethanol; hexane; acetone;

upstream raw materials:

(R)-methyl p-tolyl sulfoxide

methyl (±)-2-fluoro-2-phenylacetate

Downstream raw materials:

(2S,3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-propanol

(3S)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-butanone

(3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-butanone

(3R)-3-fluoro-3-phenyl-1-<(R)-(4-methylphenyl)sulphinyl>-2-hexanone