2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid

Base Information

Chemical Name:2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid
CAS No.:641636-54-6
Molecular Formula:C₁₅H₁₉NO₇
Molecular Weight:325.318
Hs Code.:

Synonyms:2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid

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Chemical Property of 2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid

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Technology Process of 2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid

There total 3 articles about 2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (E)-2-Acetylamino-3-(3-benzyloxy-4-ethoxycarbonylmethoxy-phenyl)-acrylic acid benzyl ester

: 641636-54-6
2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; at 20 ℃;
DOI:10.1016/j.bmcl.2003.08.064

Reference yield:

: 6272-38-4
O-benzylcatechol

: 641636-54-6
2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / K₂CO₃ / dimethylformamide / 90 °C

2: 53 percent / Pd(OAc)2; (o-tol)3P; Et₃N / acetonitrile / Heating

3: 100 percent / H₂ / Pd/C / 20 °C

With palladium diacetate; hydrogen; potassium carbonate; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In N,N-dimethyl-formamide; acetonitrile; 2: Heck reaction;
DOI:10.1016/j.bmcl.2003.08.064

Reference yield:

: 641636-58-0
(2-benzyloxy-4-bromo-phenoxy)-acetic acid ethyl ester

: 641636-54-6
2-acetylamino-3-(4-ethoxycarbonylmethoxy-3-hydroxy-phenyl)-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 53 percent / Pd(OAc)2; (o-tol)3P; Et₃N / acetonitrile / Heating

2: 100 percent / H₂ / Pd/C / 20 °C

With palladium diacetate; hydrogen; triethylamine; tris-(o-tolyl)phosphine; palladium on activated charcoal; In acetonitrile; 1: Heck reaction;
DOI:10.1016/j.bmcl.2003.08.064