3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde

Base Information

Chemical Name:3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde
CAS No.:524938-16-7
Molecular Formula:C₂₁H₂₈O₆SSi
Molecular Weight:436.601
Hs Code.:

Synonyms:3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde

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Chemical Property of 3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde

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Technology Process of 3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde

There total 5 articles about 3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 35274-53-4
2-bromo-3,4,5-tri-methoxybenzaldehyde

: 69627-08-3
1-(phenylsulfonyl)-1-(trimethylsilyl)ethene

: 524938-16-7
3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde

Guidance literature:: 2-bromo-3,4,5-tri-methoxybenzaldehyde; With morpholine; n-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 0.25h;

With n-butyllithium; In tetrahydrofuran; hexane; at -80 ℃; for 0.5h;

1-(phenylsulfonyl)-1-(trimethylsilyl)ethene; In tetrahydrofuran; hexane; at -70 - -10 ℃;
DOI:10.1023/A:1021624329438

Reference yield:

: 62762-20-3
1-phenylthio-1-trimethylsilylethene

: 524938-16-7
3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 94 percent / aq. H₂O₂; glacial AcOH / 13 h / 20 - 30 °C

2.1: morpholine; nBuLi / tetrahydrofuran; hexane / 0.25 h / -70 °C

2.2: nBuLi / tetrahydrofuran; hexane / 0.5 h / -80 °C

2.3: 40 percent / tetrahydrofuran; hexane / -70 - -10 °C

With morpholine; n-butyllithium; dihydrogen peroxide; acetic acid; In tetrahydrofuran; hexane;
DOI:10.1023/A:1021624329438

Reference yield:

: 5535-49-9
2-Chloroethyl phenyl sulfide

: 524938-16-7
3,4,5-trimethoxy-2-[2-phenylsulfonyl-2-(trimethylsilyl)ethyl]benzaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / NaOH

2.1: 89 percent / LDA / tetrahydrofuran; hexane

3.1: 94 percent / aq. H₂O₂; glacial AcOH / 13 h / 20 - 30 °C

4.1: morpholine; nBuLi / tetrahydrofuran; hexane / 0.25 h / -70 °C

4.2: nBuLi / tetrahydrofuran; hexane / 0.5 h / -80 °C

4.3: 40 percent / tetrahydrofuran; hexane / -70 - -10 °C

With morpholine; sodium hydroxide; n-butyllithium; dihydrogen peroxide; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; hexane;
DOI:10.1023/A:1021624329438