[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine

Base Information

Chemical Name:[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine
CAS No.:1232397-12-4
Molecular Formula:C₂₅H₂₇N₅O
Molecular Weight:413.522
Hs Code.:

Synonyms:[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine

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Chemical Property of [3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine

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Technology Process of [3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine

There total 5 articles about [3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1232815-53-0
(7-bromo-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-amine

: 98-80-6
phenylboronic acid

: 1232397-12-4
[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine

Guidance literature:: With sodium carbonate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; N,N-dimethyl-formamide; at 100 ℃; for 0.5h; Inert atmosphere;

Reference yield:

: 1022955-93-6
3-(2-methoxy-ethyl)-7-nitro-2,3,4,5-tetrahydro-1H-3-benzazepine

: 1232397-12-4
[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 2844.39 Torr / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

3: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With palladium 10% on activated carbon; hydrogen; palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; aniline; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/jm200758k

Reference yield:

: 1233094-95-5
7-bromo-2-methylsulfanyl-pyrrolo[2,1-f][1,2,4]triazine

: 1232397-12-4
[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl]-(7-phenyl-pyrrolo[2,1-f][1,2,4]triazin-2-yl)-amine

Guidance literature:: Multi-step reaction with 3 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 2 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; aniline / 1-methyl-pyrrolidin-2-one / 0.67 h / 180 °C / Microwave irradiation

3: palladium diacetate; sodium carbonate; triphenylphosphine / 1,4-dioxane; water; N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

With palladium diacetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; aniline; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; dichloromethane; water; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1021/jm200758k