ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate

Base Information

• Chemical Name: ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate
• CAS No.: 1616493-26-5
• Molecular Formula: C₁₈H₁₆Cl₂N₂O₃
• Molecular Weight: 379.243
• Mol file: 1616493-26-5.mol

Synonyms:ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate

Chemical Property of ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate

There total 1 articles about ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 2-[(2,6-dichloro-3-pyridinyl)carbonyl]-3-(dimethylamino)-2-propenoate (138998-49-9) + benzylamine (100-46-9) → ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate (1616493-26-5)

Guidance literature:

In diethyl ether; ethanol; at 20 ℃; for 0.666667h;

DOI:10.1021/jm500340h

Reference yield: 80.0%

ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate (1616493-26-5) → ethyl 1-benzyl-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (83785-67-5)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.1021/jm500340h

Reference yield:

ethyl 3-(benzylamino)-2-[(2,6-dichloropyridin-3-yl)-carbonyl]acrylate (1616493-26-5) → ethyl 7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-1-benzyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate (1616493-09-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

2: N,N-dimethyl-formamide / 4 h / 80 °C

With potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm500340h

upstream raw materials:

ethyl 2-[(2,6-dichloro-3-pyridinyl)carbonyl]-3-(dimethylamino)-2-propenoate

benzylamine

Downstream raw materials:

ethyl 7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-1-benzyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

7-[4-(1,3-benzothiazol-2-yl)piperazin-1-yl]-1-benzyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid

ethyl 1-benzyl-7-chloro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate