Technology Process of 2-isobutyl-3-(4-methoxyphenyl)cyclopent-2-enone
There total 4 articles about 2-isobutyl-3-(4-methoxyphenyl)cyclopent-2-enone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ethanol; sodium hydroxide;
In
toluene;
for 4h;
Inert atmosphere;
Reflux;
DOI:10.1021/ol202399c
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.33 h / 20 °C / Inert atmosphere
1.2: 20 °C / Inert atmosphere
2.1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux
2.2: 1 h / 20 °C / Inert atmosphere
3.1: ethanol; sodium hydroxide / toluene / 4 h / Inert atmosphere; Reflux
With
ethanol; dilauryl peroxide; sodium hydride; sodium hydroxide;
In
dimethyl sulfoxide; ethyl acetate; toluene; mineral oil;
DOI:10.1021/ol202399c
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tert.-butyl lithium / tetrahydrofuran / -78 - 0 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.33 h / 20 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
3.1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux
3.2: 1 h / 20 °C / Inert atmosphere
4.1: ethanol; sodium hydroxide / toluene / 4 h / Inert atmosphere; Reflux
With
ethanol; dilauryl peroxide; tert.-butyl lithium; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; dimethyl sulfoxide; ethyl acetate; toluene; mineral oil;
DOI:10.1021/ol202399c
