{2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane

Base Information

Chemical Name:{2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane
CAS No.:220466-92-2
Molecular Formula:C₂₇H₄₆O₂Si
Molecular Weight:430.747
Hs Code.:

Synonyms:{2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane

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Chemical Property of {2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane

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Technology Process of {2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane

There total 6 articles about {2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 13154-24-0
triisopropylsilyl chloride

: 220467-08-3
2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethanol

: 220466-92-2
{2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; for 12h;
DOI:10.1016/S0040-4039(98)02535-0

Reference yield:

: 104758-32-9
(1R,2R)-2-Bromomethyl-1-methoxycarbonylmethyl-2-methyl-3-methylenecyclopentane

: 220466-92-2
{2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / LiAlH₄ / diethyl ether / 1.5 h / -60 °C

2: 93 percent / KN(TMS)2 / tetrahydrofuran / 0 °C

3: 93 percent / 1,2-dimethoxy-ethane; hexamethylphosphoric acid triamide / 48 h / 100 °C

4: 70 percent / 1.) DIBAH; 2.) H₃O⁽¹⁺⁾ / toluene / 0.5 h / 0 °C

5: 92 percent / LiAlH₄ / diethyl ether / 0.5 h / 0 °C

6: 97 percent / imidazole / dimethylformamide / 12 h

With 1H-imidazole; lithium aluminium tetrahydride; oxonium; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(98)02535-0

Reference yield:

: 99277-05-1
(1R,2R)-2-Bromomethyl-1-(2-hydroxyethyl)-2-methyl-3-methylenecyclopentane

: 220466-92-2
{2-[(1R,2R)-2-(2-Benzyloxy-ethyl)-1-methyl-5-methylene-cyclopentyl]-ethoxy}-triisopropyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / KN(TMS)2 / tetrahydrofuran / 0 °C

2: 93 percent / 1,2-dimethoxy-ethane; hexamethylphosphoric acid triamide / 48 h / 100 °C

3: 70 percent / 1.) DIBAH; 2.) H₃O⁽¹⁺⁾ / toluene / 0.5 h / 0 °C

4: 92 percent / LiAlH₄ / diethyl ether / 0.5 h / 0 °C

5: 97 percent / imidazole / dimethylformamide / 12 h

With 1H-imidazole; lithium aluminium tetrahydride; oxonium; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; 1,2-dimethoxyethane; diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1016/S0040-4039(98)02535-0