N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

Base Information

Chemical Name:N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide
CAS No.:1383618-48-1
Molecular Formula:C₂₅H₂₅FN₄O
Molecular Weight:416.498
Hs Code.:

Synonyms:N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

Chemical Property:

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Technology Process of N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

There total 6 articles about N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1383618-47-0
N-(5-(6-chloro-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

: 1993-03-9
o-fluorophenylboronic acid

: 1383618-48-1
N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

Guidance literature:: With sodium carbonate; bis-triphenylphosphine-palladium(II) chloride; In water; isopropyl alcohol; at 80 ℃; for 12h; Inert atmosphere;

Reference yield:

: 5337-93-9
4'-methylpropiophenone

: 1383618-48-1
N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid / 0 - 10 °C

2: bromine / dichloromethane / 20 °C

3: acetonitrile / 16 h / 80 °C

4: acetic acid; iron / ethanol; water / 6 h / 80 °C

5: pyridine / acetonitrile / 4 h / 20 °C

6: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / isopropyl alcohol; water / 12 h / 80 °C / Inert atmosphere

With pyridine; bromine; nitric acid; iron; sodium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

: 50630-41-6
1-(4'-methyl-3'-nitrophenyl)-propane-1-one

: 1383618-48-1
N-(5-(6-(2-fluorophenyl)-3-methylimidazo[1,2-b]pyridazin-2-yl)-2-methylphenyl)pivalamide

Guidance literature:: Multi-step reaction with 5 steps

1: bromine / dichloromethane / 20 °C

2: acetonitrile / 16 h / 80 °C

3: acetic acid; iron / ethanol; water / 6 h / 80 °C

4: pyridine / acetonitrile / 4 h / 20 °C

5: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / isopropyl alcohol; water / 12 h / 80 °C / Inert atmosphere

With pyridine; bromine; iron; sodium carbonate; acetic acid; bis-triphenylphosphine-palladium(II) chloride; In ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;