(Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester

Base Information

• Chemical Name: (Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester
• CAS No.: 741261-92-7
• Molecular Formula: C₁₉H₁₈FN₃O₄S
• Molecular Weight: 403.434
• Mol file: 741261-92-7.mol

Synonyms:(Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester

Chemical Property of (Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester

There total 1 articles about (Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-methylthiosemicarbazide (6610-29-3) + methyl 2-(4-fluorobenzoyl)-4,5-methylenedioxyphenylacetate (197369-12-3) → (Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester (741261-92-7)

Guidance literature:

With hydrogenchloride; In methanol; for 48h; Heating;

DOI:10.1016/j.bmc.2004.04.015

Reference yield: 85.0%

(Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester (741261-92-7) → (Z)-2-[(4-fluorophenyl)-(4-methylsemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester

Guidance literature:

With dihydrogen peroxide; sodium methylate; In methanol; at 20 ℃;

DOI:10.1016/j.bmc.2004.04.015

Reference yield: 71.0%

(Z)-2-[(4-fluorophenyl)-(4-methylthiosemicarbazono)-methyl]-4,5-methylenedioxyphenylacetic acid methyl ester (741261-92-7) → C18H16FN3O5

Guidance literature:

With dihydrogen peroxide; sodium methylate; In methanol; at 20 ℃; for 24h;

DOI:10.1016/j.farmac.2004.11.012

upstream raw materials:

4-methylthiosemicarbazide

methyl 2-(4-fluorobenzoyl)-4,5-methylenedioxyphenylacetate