N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide

Base Information

Chemical Name:N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide
CAS No.:851897-01-3
Molecular Formula:C₁₉H₂₁ClFN₃O₄S
Molecular Weight:441.911
Hs Code.:

Synonyms:N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide

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Chemical Property of N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide

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Technology Process of N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide

There total 2 articles about N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 114500-32-2
4-methyl-3-(morpholine-4-sulfonyl)phenylamine

: 96980-64-2
N-(2-chloroacetyl)-3-chloro-4-fluoroaniline

: 851897-01-3
N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide

Guidance literature:: N-(2-chloroacetyl)-3-chloro-4-fluoroaniline; With potassium iodide; In N,N-dimethyl-formamide; at 45 - 48 ℃; for 1h;

4-methyl-3-(morpholine-4-sulfonyl)phenylamine; In N,N-dimethyl-formamide; at 45 - 48 ℃; for 17h; Sealed tube;
DOI:10.1002/cmdc.201900329

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 851897-01-3
N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane

2.1: potassium iodide / N,N-dimethyl-formamide / 1 h / 45 - 48 °C

2.2: 17 h / 45 - 48 °C / Sealed tube

With triethylamine; potassium iodide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201900329

Reference yield: 40.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 851897-01-3
N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide

: N-(3-chloro-4-fluorophenyl)-2-(methyl(4-methyl-3 (morpholinosulfonyl)phenyl)amino)acetamide

Guidance literature:: formaldehyd; N-(3-chloro-4-fluorophenyl)-2-((4-methyl-(morpholinosulfonyl) phenyl)amino)acetamide; In chloroform; at 65 - 68 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In chloroform; at 65 - 68 ℃; for 16h;

formaldehyd; Further stages;
DOI:10.1002/cmdc.201900329