9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine

Base Information

• Chemical Name: 9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine
• CAS No.: 652173-18-7
• Molecular Formula: C₁₈H₂₀N₈O₃
• Molecular Weight: 396.409
• Mol file: 652173-18-7.mol

Synonyms:9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine

Chemical Property of 9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine

There total 1 articles about 9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

9-benzyl-9H-purin-6-ylamine (4261-14-7) + 4-azido-4-deoxy-α/β-L-rhamnopyranoside → 9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine (652173-18-7)

Guidance literature:

With acetic acid; In methanol; for 48h; Heating;

DOI:10.1039/b307795k

Reference yield:

9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine (652173-18-7) → (2S,3R,4R,5R,6S)-5-Amino-2-(9-benzyl-9H-purin-6-ylamino)-6-methyl-tetrahydro-pyran-3,4-diol (1053693-91-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 0.666667h;

DOI:10.1039/b307795k

Reference yield:

9-benzyl-6-(4'-azido-4'-deoxy-β-L-rhamnopyranosylamino)-9H-purine (652173-18-7) → 9-benzyl-6-[4'-deoxy-4'-(dodecanoylglycyl)amino-β-L-rhamnopyranosylamino]-9H-purine

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd/C / aq. methanol / 0.67 h / 20 °C

2: 27 mg / N-hydroxybenzotriazole monohydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 12 h / 20 °C

With hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;

DOI:10.1039/b307795k

upstream raw materials:

9-benzyl-9H-purin-6-ylamine

Downstream raw materials:

(2S,3R,4R,5R,6S)-5-Amino-2-(9-benzyl-9H-purin-6-ylamino)-6-methyl-tetrahydro-pyran-3,4-diol