(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate

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Chemical Name:(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate
CAS No.:1442445-55-7
Molecular Formula:C₂₉H₃₅Cl₂N₅O₃
Molecular Weight:572.535
Hs Code.:

Synonyms:(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate

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Chemical Property of (R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate

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Technology Process of (R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate

There total 6 articles about (R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1442445-54-6
(R)-1-(1-(2,4-dichlorophenyl)ethyl)-6-(piperazin-1-yl)-1H-indazole

: 37784-17-1,59433-50-0
N-(tert-butoxycarbonyl)-D-proline

: 1442445-55-7
(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1442445-48-8
(S)-2,4-dichloro-1-(1-chloroethyl)benzene

: 1442445-55-7
(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: caesium carbonate / 1-methyl-pyrrolidin-2-one / 0.17 h / Heating

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / 100 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In 1-methyl-pyrrolidin-2-one; dichloromethane; toluene;

Reference yield:

: 1442445-49-9
(R)-6-bromo-1-(1-(2,4-dichlorophenyl)ethyl)-1H-indazole

: 1442445-55-7
(R)-tert-butyl 2-(4-(1-((R)-1-(2,4-dichlorophenyl)ethyl)-1H-indazol-6-yl)piperazine-1-carbonyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 18 h / 100 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: HATU; N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In dichloromethane; toluene;