5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole

Base Information

• Chemical Name: 5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole
• CAS No.: 159727-71-6
• Molecular Formula: C₂₂H₂₆N₂O₅
• Molecular Weight: 398.459
• Mol file: 159727-71-6.mol

Synonyms:5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole

Chemical Property of 5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole

There total 2 articles about 5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

2-<2-<5-(3-chloropropyl)furanyl>>-2-methyl-1,3-dioxolane (159727-70-5) + 4-(5-methyl-1,2,4-oxadiazol-3-yl)-2,6-dimethylphenol (156787-42-7) → 5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole (159727-71-6)

Guidance literature:

With potassium hydroxide; potassium iodide; In acetonitrile; for 48h; Heating;

DOI:10.1021/jm00050a014

Reference yield:

2-(furan-2-yl)-2-methyl-[1,3]dioxolane (69536-36-3) → 5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole (159727-71-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) t-BuLi / 1.) THF, pentane, -72 deg C, 10 min, 2.) THF, pentane, HMPA, RT, 16 h

2: 25 percent / KOH, KI / acetonitrile / 48 h / Heating

With potassium hydroxide; tert.-butyl lithium; potassium iodide; In acetonitrile;

DOI:10.1021/jm00050a014

Reference yield: 92.0%

5-methyl-3-<3,5-dimethyl-4-<3-<2-<5-(2-methyl-1,3-dioxolan-2-yl)>furanyl>propyl>phenoxy>-1,2,4-oxadiazole (159727-71-6) → 1-<5-<3-<2,6-dimethyl-4-(5-methyl-1,2,4-oxadiazoyl)phenoxy>propyl>-2-furanyl>ethanone

Guidance literature:

With pyridinium p-toluenesulfonate; In acetone; for 20h; Ambient temperature;

DOI:10.1021/jm00050a014

upstream raw materials:

2-<2-<5-(3-chloropropyl)furanyl>>-2-methyl-1,3-dioxolane

4-(5-methyl-1,2,4-oxadiazol-3-yl)-2,6-dimethylphenol

2-(furan-2-yl)-2-methyl-[1,3]dioxolane