2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate

Base Information

Chemical Name:2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate
CAS No.:1351067-04-3
Molecular Formula:C₃₀H₃₆N₂O₃Si
Molecular Weight:500.713
Hs Code.:

Synonyms:2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate

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Chemical Property of 2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate

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Technology Process of 2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate

There total 4 articles about 2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1351067-39-4
2-methyl-3-(quinolin-8-ylcarbamoyl)phenyl acetate

: 111409-79-1
1-bromo-2-(triisopropylsilyl)acetylene

: 1351067-04-3
2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate

Guidance literature:: With Bis<2-(N,N-dimethylamino)aethyl>aether; sodium carbonate; nickel dichloride; In toluene; at 100 ℃; for 24h; Inert atmosphere; Schlenk technique; Glovebox;
DOI:10.1021/acs.joc.5b00669

Reference yield:

: 168899-58-9
3-acetoxy-2-methylbenzoic acid

: 1351067-04-3
2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 5 h / 0 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: cesium acetate; palladium diacetate / toluene / 15 h / 110 °C / Inert atmosphere

With oxalyl dichloride; cesium acetate; palladium diacetate; triethylamine; N,N-dimethyl-formamide; In dichloromethane; toluene;
DOI:10.1021/ol203100u

Reference yield:

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1351067-04-3
2-methyl-3-(quinolin-8-ylcarbamoyl)-4-((triisopropylsilyl)-ethynyl)phenyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate

2: cesium acetate; palladium diacetate / toluene / 15 h / 110 °C / Inert atmosphere

With N-Bromosuccinimide; cesium acetate; palladium diacetate; silver nitrate; In toluene;
DOI:10.1021/ol203100u