(S)-trans-2-phenylcyclohexyl carbamate

Base Information

• Chemical Name: (S)-trans-2-phenylcyclohexyl carbamate
• CAS No.: 129966-10-5
• Molecular Formula: C₁₃H₁₇NO₂
• Molecular Weight: 219.283
• Mol file: 129966-10-5.mol

Synonyms:(S)-trans-2-phenylcyclohexyl carbamate

Chemical Property of (S)-trans-2-phenylcyclohexyl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-trans-2-phenylcyclohexyl carbamate

There total 1 articles about (S)-trans-2-phenylcyclohexyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

sodium isocyanate (917-61-3) + (1S,2R)-trans-2-phenyl-1-cyclohexanol (34281-92-0) → (S)-trans-2-phenylcyclohexyl carbamate (129966-10-5)

Guidance literature:

With trifluoroacetic acid; In benzene; for 40h;

DOI:10.1021/ja00177a029

Reference yield:

(S)-trans-2-phenylcyclohexyl carbamate (129966-10-5) → (S)-trans-2-phenylcyclohexyl N-sulfinylcarbamate (107575-41-7,130060-02-5)

Guidance literature:

With pyridine; thionyl chloride; In benzene; for 0.25h;

DOI:10.1021/ja00177a029

Reference yield:

(S)-trans-2-phenylcyclohexyl carbamate (129966-10-5) → Ethyl-carbamic acid (1R,2S)-2-phenyl-cyclohexyl ester (129966-17-2)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine, SOCl₂ / benzene / 0.25 h

2: SnCl₄ / CH₂Cl₂ / 0.33 h / -78 °C

3: Huenig's base / CH₂Cl₂ / 0.5 h / -10 °C

4: 2.) NH₄OH, piperidine / 1.) ether, -78 deg C, 40 min, 2.) reflux, 40 h

With piperidine; pyridine; ammonium hydroxide; thionyl chloride; tin(IV) chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; benzene;

DOI:10.1021/ja00177a029

upstream raw materials:

sodium isocyanate

(1S,2R)-trans-2-phenyl-1-cyclohexanol

Downstream raw materials:

(S)-trans-2-phenylcyclohexyl N-sulfinylcarbamate

1-carbonyl>amino>-2-cyclohexene

4-carbonyl>amino>-2(E)-octene

1-carbonyl>amino>-2-methyl-2-cyclohexene

Refernces