(2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

Base Information

Chemical Name:(2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane
CAS No.:568571-87-9
Molecular Formula:C₃₀H₃₄O₅
Molecular Weight:474.597
Hs Code.:

Synonyms:(2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

Suppliers and Price of (2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

There total 13 articles about (2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 568572-01-0
(2S,3R,6S,7S)-3-Benzyloxy-2-benzyloxymethyl-7-iodomethyl-6-(4-methoxy-benzyloxy)-oxepane

: 568571-87-9
(2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0040-4039(03)00949-3

Reference yield:

: 568571-86-8
[(2R,3S,6R,7S)-6-Benzyloxy-7-benzyloxymethyl-3-(4-methoxy-benzyloxy)-oxepan-2-yl]-methanol

: 568571-87-9
(2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / I₂; imidazole; PPh₃ / benzene / 0.58 h / 20 °C

2: 95 percent / potassium t-butoxide / tetrahydrofuran / 1.5 h / 0 °C

With 1H-imidazole; potassium tert-butylate; iodine; triphenylphosphine; In tetrahydrofuran; benzene;
DOI:10.1021/ja042686r

Reference yield:

: (2R,4aR,6R,7R,9aS)-7-Benzyloxy-2-phenyl-hexahydro-1,3,5-trioxa-benzocycloheptene-6-carbaldehyde

: 568571-87-9
(2S,3R,6S)-3-Benzyloxy-2-benzyloxymethyl-6-(4-methoxy-benzyloxy)-7-methylene-oxepane

Guidance literature:: Multi-step reaction with 7 steps

1: 5.59 g / NaBH₄ / methanol; CH₂Cl₂ / 0.33 h / 0 °C

2: potassium t-butoxide / tetrahydrofuran / 0.33 h / 20 °C

3: camphorsulfonic acid / methanol / 14.5 h / 20 °C

4: camphorsulfonic acid / CH₂Cl₂ / 4 h / 20 °C

5: 7.04 g / DIBALH / CH₂Cl₂; hexane / -78 - 0 °C

6: 94 percent / I₂; imidazole; PPh₃ / benzene / 0.58 h / 20 °C

7: 95 percent / potassium t-butoxide / tetrahydrofuran / 1.5 h / 0 °C

With 1H-imidazole; sodium tetrahydroborate; camphor-10-sulfonic acid; potassium tert-butylate; iodine; diisobutylaluminium hydride; triphenylphosphine; In tetrahydrofuran; methanol; hexane; dichloromethane; benzene;
DOI:10.1021/ja042686r