4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester

Base Information

• Chemical Name: 4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester
• CAS No.: 190436-92-1
• Molecular Formula: C₂₂H₂₈O₇S
• Molecular Weight: 436.526

Synonyms:4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester

Chemical Property of 4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester

Chemical Property:

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Technology Process of 4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester

There total 3 articles about 4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-4-(2,6-Dimethoxy-4-methyl-phenyl)-5-hydroxy-pent-2-enoic acid methyl ester (164921-89-5) → 4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester (190436-92-1)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂ / Pd(OH)2-C / methanol / 3 h

2: pyridine; DMAP / 2 h / 20 °C

With pyridine; dmap; hydrogen; palladium hydroxide - carbon; In methanol;

DOI:10.1021/jo010500q

Reference yield:

4-(2,6-dimethoxy-4-methyl-phenyl)-5-hydroxy-pentanoic acid methyl ester (471260-97-6) + p-toluenesulfonyl chloride (98-59-9) → 4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester (190436-92-1)

Guidance literature:

With pyridine; dmap; at 20 ℃; for 2h;

DOI:10.1021/jo010500q

Reference yield:

p-toluenesulfonyl chloride (98-59-9) + (E)-4-(2,6-Dimethoxy-4-methyl-phenyl)-5-hydroxy-pent-2-enoic acid methyl ester (164921-89-5) → 4-(2,6-Dimethoxy-4-methyl-phenyl)-5-(toluene-4-sulfonyloxy)-pentanoic acid methyl ester (190436-92-1)

Guidance literature:

With pyridine; hydrogen; palladium dihydroxide; Multistep reaction; 1.) MeOH;

DOI:10.1016/S0040-4039(97)00479-6

upstream raw materials:

p-toluenesulfonyl chloride

(E)-4-(2,6-Dimethoxy-4-methyl-phenyl)-5-hydroxy-pent-2-enoic acid methyl ester

4-(2,6-dimethoxy-4-methyl-phenyl)-5-hydroxy-pentanoic acid methyl ester

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