C₂₄H₂₃ClNO₃P

Base Information

• Chemical Name: C₂₄H₂₃ClNO₃P
• CAS No.: 1616557-94-8
• Molecular Formula: C₂₄H₂₃ClNO₃P
• Molecular Weight: 439.878
• Mol file: 1616557-94-8.mol

Synonyms:C₂₄H₂₃ClNO₃P

Chemical Property of C₂₄H₂₃ClNO₃P

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₄H₂₃ClNO₃P

There total 13 articles about C₂₄H₂₃ClNO₃P which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

C25H25ClNO3P (1627704-48-6) → C24H23ClNO3P (1616557-94-8)

Guidance literature:

With water; lithium hydroxide; In tetrahydrofuran; methanol; at 100 ℃;

DOI:10.1016/j.bmcl.2014.05.036

Reference yield:

diethyl (4-bromophenyl)phosphonate (20677-12-7) → C24H23ClNO3P (1616557-94-8)

Guidance literature:

Multi-step reaction with 12 steps

1.1: trimethylsilyl bromide

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

3.1: tetrahydrofuran / -78 °C

4.1: water / 90 °C

5.1: carbonochloridic acid 1-chloro-ethyl ester / toluene / Reflux

5.2: Reflux

6.1: triethylamine / dichloromethane

7.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 80 °C

8.1: ozone / methanol / -78 °C

9.1: potassium permanganate / acetone

10.1: hydrogenchloride / Reflux

11.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

12.1: lithium hydroxide; water / tetrahydrofuran; methanol / 100 °C

With hydrogenchloride; potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; trimethylsilyl bromide; carbonochloridic acid 1-chloro-ethyl ester; water; sodium tris(acetoxy)borohydride; potassium carbonate; ozone; triethylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; acetone; toluene; 7.1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.036

Reference yield:

1,4-bromoiodobenzene (589-87-7) → C24H23ClNO3P (1616557-94-8)

Guidance literature:

Multi-step reaction with 13 steps

1.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; potassium acetate / tetrahydrofuran / 22 h / 68 °C

2.1: trimethylsilyl bromide

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane

4.1: tetrahydrofuran / -78 °C

5.1: water / 90 °C

6.1: carbonochloridic acid 1-chloro-ethyl ester / toluene / Reflux

6.2: Reflux

7.1: triethylamine / dichloromethane

8.1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; 1,2-dimethoxyethane / 80 °C

9.1: ozone / methanol / -78 °C

10.1: potassium permanganate / acetone

11.1: hydrogenchloride / Reflux

12.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane

13.1: lithium hydroxide; water / tetrahydrofuran; methanol / 100 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; trimethylsilyl bromide; carbonochloridic acid 1-chloro-ethyl ester; water; potassium acetate; sodium tris(acetoxy)borohydride; potassium carbonate; ozone; triethylamine; N,N-dimethyl-formamide; lithium hydroxide; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; acetone; toluene; 8.1: |Suzuki Coupling;

DOI:10.1016/j.bmcl.2014.05.036

upstream raw materials:

1,4-bromoiodobenzene

diethyl (4-bromophenyl)phosphonate

4-bromophenylphosphonic acid

(4-Bromophenyl)phosphonsaeure-dichlorid

Downstream raw materials:

C₄₅H₄₇ClF₃N₄O₇PS₃

Refernces