3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide

Base Information

Chemical Name:3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide
CAS No.:90521-13-4
Molecular Formula:C₁₃H₁₁ClN₆O₂
Molecular Weight:318.722
Hs Code.:

Synonyms:3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide

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Chemical Property of 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide

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Technology Process of 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide

There total 5 articles about 3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 90521-12-3
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid (4-methoxy-benzyl)-phenyl-amide

: 90521-13-4
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide

Guidance literature:: With methoxybenzene; trifluoroacetic acid; for 18h; Ambient temperature;
DOI:10.1021/jm00385a018

Reference yield:

: 113942-31-7
benzyl 3-(2-chloroethyl)-3H-4-oxoimidazo<5,1-d>-1,2,3,5-tetrazine-8-carboxylate

: 90521-13-4
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / H₂ / palladium on charcoal (10percent)

2: 99 percent / thionyl chloride, N,N-dimethylformamide / 2.5 h / Heating

3: 66 percent / tetrahydrofuran; H₂O / 0.5 h

With thionyl chloride; hydrogen; N,N-dimethyl-formamide; palladium on activated charcoal; In tetrahydrofuran; water;
DOI:10.1021/jm00167a018

Reference yield:

: C₁₈H₁₅N₅O₂

: 90521-13-4
3-(2-Chloro-ethyl)-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 2 steps

1: ethyl acetate / 120 h / Ambient temperature

2: 59 percent / TFA, anisole / 18 h / Ambient temperature

With methoxybenzene; trifluoroacetic acid; In ethyl acetate;
DOI:10.1021/jm00385a018