(+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one

Base Information

Chemical Name:(+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one
CAS No.:119880-01-2
Molecular Formula:C₁₅H₁₃NO₃S
Molecular Weight:287.339
Hs Code.:

Synonyms:(+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one

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Chemical Property of (+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one

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Technology Process of (+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one

There total 17 articles about (+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 153898-60-3
1-Benzenesulfonyl-3-iodomethyl-2,3-dihydro-1H-indol-6-ol

: 119880-01-2
(+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield: 80.0%

: 119880-04-5
6-hydroxy-3-(((methanesulfonyl)oxy)methyl)-1-(phenylsulfonyl)indoline

: 119880-01-2
(+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 24 ℃; for 0.166667h;

Reference yield:

: 119879-90-2
5-(Benzyloxy)-2-bromophenylamine

: 119880-01-2
(+/-)-N-(phenylsulfonyl)-1,2,7,7a-tetrahydrocycloprop<1,2-c>indol-4-one

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / pyridine / tetrahydrofuran / 40 h / 66 °C

2: 76 percent / NaH / dimethylformamide / 2 h / 25 °C

3: 92 percent / Bu₃SnH, AIBN / benzene / 2 h / 80 °C

4: 1.) ozone, 2.) NaBH₄ / 1.) EtOH, CH₂Cl₂, -78 deg C, 8 min, 2.) EtOH, H₂O, -78 to 24 deg C, 9 h

5: 73 percent / Et₃N / CH₂Cl₂ / 1 h / 0 °C

6: 84 percent / H₂ / 10percent Pd/C / tetrahydrofuran / 9 h / 24 °C / 760 Torr

7: 80 percent / NaH / tetrahydrofuran / 0.17 h / 24 °C

With pyridine; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; sodium hydride; ozone; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1021/jo00267a004