3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone

Base Information

• Chemical Name: 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone
• CAS No.: 104729-36-4
• Molecular Formula: C₂₈H₃₈O₃S
• Molecular Weight: 454.674
• Mol file: 104729-36-4.mol

Synonyms:3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone

Chemical Property of 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone

There total 16 articles about 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-phenylsulfonyl-23,24-bisnorchol-6-ene (116653-47-5) → 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone (104729-36-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; 20 deg C, 20 min, then reflux, 20 min;

Reference yield:

3β-benzoyloxy-22-hydroxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-23,24-bisnorchol-6-ene (116653-45-3) → 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone (104729-36-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 81 percent / pyridine / 5 h / 0 °C

2: 1.) LiBr*2H₂O, Li₂CO₃ / 1.) DMF, 80 deg C, 1h, 2.) 80 deg C, 3h

3: 89 percent / LiAlH₄ / tetrahydrofuran / 20 deg C, 20 min, then reflux, 20 min

With pyridine; lithium aluminium tetrahydride; lithium carbonate; lithium bromide; In tetrahydrofuran;

Reference yield:

3β-benzoyloxy-5α,8α-ergosta-6,22-dieno-<5,8-b>1',2',3',4'-tetrahydrophthalazino-1',4'-dione (81126-45-6) → 3β-hydroxy-23,24-bisnorchola-5,7-dien-22-yl phenyl sulfone (104729-36-4)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) O₃, 2.) NaBH₄ / 1.) CH₂Cl₂, pyridine, -60 deg C, 10 min, 2.) MeOH, CH₂Cl₂, -50 deg, 10 min, then room temp., 2h

2: 81 percent / pyridine / 5 h / 0 °C

3: 1.) LiBr*2H₂O, Li₂CO₃ / 1.) DMF, 80 deg C, 1h, 2.) 80 deg C, 3h

4: 89 percent / LiAlH₄ / tetrahydrofuran / 20 deg C, 20 min, then reflux, 20 min

With pyridine; sodium tetrahydroborate; lithium aluminium tetrahydride; lithium carbonate; ozone; lithium bromide; In tetrahydrofuran;

upstream raw materials:

3β-benzoyloxy-5α,8α-(1,4-dioxo-1,2,3,4-tetrahydrophthalazine-2,3-diyl)-22-phenylsulfonyl-23,24-bisnorchol-6-ene

C₃₈H₄₄N₂O₆S

benzyloxy-3β phenylsulfonyl-22 (phenyl-4' urazolo-1',2')-5α,8α bis-nor-23,24-cholene-6

sodium benzenesulfonate

Downstream raw materials:

(22ξ,24R)-3β,24,25-trihydroxy-22-phenylsulfonylcholesta-5,7-diene

(20S)-3β-(tert-butyldimethylsilyloxy)-22-phenylsulfonyl-23,24-dinorchola-5,7-diene

(20S,22ξ,24R)-3β-(tert-butyldimethylsilyloxy)-22-phenylsulfonylcholesta-5,7-diene-24,25-diol

(5Z,7E)-(3S,24R)-24,25-dihydroxy-9,10-secocholesta-5,7,10(19)-trien-3β-yl β-D-glycopyranuronic acid